Just Like a Woman tells the poignant tale of two women, barely more than casual acquaintances, who, upon escaping the prisons of their unhappy marriages, embark on a revealing journey of self-discovery which leads them to the importance – and true meaning – of friendship.

Mona (Golshifteh Farahani), 26, an immigrant from North Africa, runs her in-laws’ mini market in Chicago. She’s married to Mourad, a man who can’t stand up to his authoritarian mother. Mona is harassed by her mother-in-law because after five years of marriage, she hasn’t be able to get pregnant, something that’s considered a shame and a taboo in her culture.

Marilyn (Sienna Miller), 29, is a receptionist at a computer repair company. Her marriage with Harvey is on the ropes. The only thing in her life that makes her happy is her belly dance class, a passion shared by Mona. Dancing at family gatherings lifts her spirits up and makes her forget the misery of her daily life. Marilyn shops at Mona’s mini-market. They’ve become friends.

One morning, Mona’s mother-in-law is found dead in her bed. Mona realizes that she mixed the wrong dose while preparing her medicine. Realizing that she might be accused of murder, Mona runs away and flees Chicago by bus.

Marilyn loses her job because of the recession. When she gets home, she finds out that her husband is cheating on her. With nothing left to lose, Mona decides to go to Santa Fe to enter a contest hoping to join a famous belly dance company.

Mona and Marilyn run into each other on a rest area on the side of a highway. They decide to continue the trip together. They cross the USA, pitching their tent in trailer parks and in the middle of the desert.